2006, English, Article edition: Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase. Ratel, David; Ravanat, Jean-Luc; Charles, Marie-Pierre; ...

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Bookmark: http://trove.nla.gov.au/version/200066
Physical Description
  • text
Published
  • HAL - CCSD
  • 2006
Language
  • English

Edition details

Title
  • Undetectable levels of N6-methyl adenine in mouse DNA: Cloning and analysis of PRED28, a gene coding for a putative mammalian DNA adenine methyltransferase.
Author
  • Ratel, David
  • Ravanat, Jean-Luc
  • Charles, Marie-Pierre
  • Platet, Nadine
  • Breuillaud, Lionel
  • Lunardi, Joël
  • Berger, François
  • Wion, Didier
Published
  • HAL - CCSD
  • 2006
Physical Description
  • text
Subjects
Notes
  • Three methylated bases, 5-methylcytosine, N4-methylcytosine and N6-methyladenine (m6A), can be found in DNA. However, to date, only 5-methylcytosine has been detected in mammalian genomes. To reinvestigate the presence of m6A in mammalian DNA, we used a highly sensitive method capable of detecting one N6-methyldeoxyadenosine per million nucleosides. Our results suggest that the total mouse genome contains, if any, less than 10(3) m6A. Experiments were next performed on PRED28, a putative mammalian N6-DNA methyltransferase. The murine PRED28 encodes two alternatively spliced RNA. However, although recombinant PRED28 proteins are found in the nucleus, no evidence for an adenine-methyltransferase activity was detected.
  • HAL:inserm-00390713, version 1
  • HAL:http:/​/​www.hal.inserm.fr/​inserm-00390713/​en/​
  • PUBMED:16684535
  • DOI:10.1016/​j.febslet.2006.04.074
Language
  • English
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