One dose of 500 mg metronidazole (M) was given to 21 patients before appendectomy and the concentrations of the parent compound and the major metabolite hydroxymetronidazole (OH-M), assayed in serum and tissue homogenates of appendix and subcutaneous tissues by high pressure liquid chromatography. Based on determinations in one specimen per patient during the initial 1–25—4 h after end of the 50 min infusion, the levels of M in relation to serum were 60–8% (±s.d. 19.8) for the appendix and 29.0% ±8.7 for subcutaneous tissue. The corresponding values for OH-M were 103.9±28.2 and 57.0% ± 16.8. The slope of the log-linear regression curves of M corresponded to elimination half-life ( T γ ) values of 5.2 h in serum, 2.7 h in appendix and 2.6 h in subcutis tissue, but the differences were not statistically significant. The values of OH-M were similar for serum and appendix. OH-M had T ½ of 7.9 and 6.1 h for serum and subcutaneous tissue and 21.3 h in the appendix, but the values were not significantly different
Copyright (C) 1983, The British Society for Antimicrobial Chemotherapy
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