Antagonism of &eegr;Mactarn antibiotics by second and third generation cephalosporins was studied in 28 clinical strains of Serratia marcescens . and Aeromonas hydrophila . Of the antibiotics tested, both cefoxitin and N-formimidoyl thienamycin (N-f-thienamycin) were capable of antagonism in Ser. marcescens (17 of 20) but in Aerom. hydrophila (7 of 8), only cefoxitin induced antagonism. Antagonism was observed to the greatest degree with cefotaxime and cefoperazone; intermediate with cefamandole and latamoxef (moxalactam) and essentially none with N-f-thienamycin. Inducible βlactamase was found in all strains of both genera which exhibited antagonism. The induced &eegr;-lactamase showed enhanced inacti-vation for other antibiotics in only four strains with none occurring in Aeromonas.
Copyright (C) 1983, The British Society for Antimicrobial Chemotherapy
In order to set up a list of libraries that you have access to,
you must first login
or sign up.
Then set up a personal list of libraries from your profile page by
clicking on your user name at the top right of any screen.