2011-08-01, English, Article, Journal or magazine article edition: Camptothecins and their novel anticancer properties evaluated by using pass method.(Original Article)(Report) Behrangi, N.; Hashemi, M.; Doustar, Y.; ...

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Physical Description
  • 2184 words
  • Report
  • Magazine/​Journal article
Published
  • American-Eurasian Network for Scientific Information, 2011 August
Language
  • English

Edition details

Title
  • Camptothecins and their novel anticancer properties evaluated by using pass method.(Original Article)(Report)
Also Titled
  • Camptothecins and their novel anticancer properties evaluated by using pass method.
Appears In
  • Advances in Environmental Biology, 2011 August, p.2551(6) (ISSN: 1995-0756)
Author
  • Behrangi, N.
  • Hashemi, M.
  • Doustar, Y.
  • Borna H.
Published
  • American-Eurasian Network for Scientific Information, 2011 August
Physical Description
  • 2184 words
  • Report
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • Chemotherapy is one of the approaches applied for cancer treatment. Most of the drugs used today in chemotherapy have natural origins and were first discovered in plants, fruits and microorganisms. Camptothecins are natural anticancer agents initially extracted from bark and leaves of Camptotheca acuminate trees. This study examined the anticancer bioactivity as well as Drug-likeness of these compounds. Accordingly, the structures of the following compounds were drawn with ChemAxon and evaluated with PASS software for about 1500 possible activities mechanisms and targets: Camptothecin(CPT), Irinotecan, Topotecan, 9-Nitrocamptothecin and 10-Hydroxycamptothecine. In addition, further intergroup analyzes were accomplished. Results represented that all compounds have strong Antineoplastic Alkaloid ,Topoisomerase I inhibitory and DNA intercatalor activities with higher than 0.6 theresholds. This is interesting that they have high drug-liklinesses simultaneously. So all camptothecins were categorized in three main groups based on their strong exhibited activity. Consequently, Camptothecin (CPT), 10-Hydroxycamptothecin(10-HCPT),with 0.87 mean activities were the strongest anticancer agents among the other camptothecins.
Terms of Use
  • COPYRIGHT 2011 American-Eurasian Network for Scientific Information
Language
  • English
Database
  • Gale Expanded Academic
  • Gale Academic OneFile
Identifier
  • 271052356

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