2011-09-30, English, Article, Report edition: Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats.(Research)(Report) Ali, Eman Noaman; Mansour, Somaya Zakaria

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Physical Description
  • 8800 words
  • Report
  • Magazine/​Journal article
Published
  • BioMed Central Ltd., 2011 Sept 30
Language
  • English

Edition details

Title
  • Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats.(Research)(Report)
Also Titled
  • Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats.
Appears In
  • Chinese Medicine, v.6, 2011 Sept 30, p.36 (ISSN: 1749-8546)
Author
  • Ali, Eman Noaman
  • Mansour, Somaya Zakaria
Published
  • BioMed Central Ltd., 2011 Sept 30
Physical Description
  • 8800 words
  • Report
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • Background Interstitial pulmonary fibrosis is characterized by an altered cellular composition of the alveolar region with excessive deposition of collagen. Lung inflammation is also common in pulmonary fibrosis. This study aims to test the inhibition of 5-lipooxygenase (5-LOX) by boswellic acid (BA) extract in an experimental model of pulmonary fibrosis using bleomycin (BL). Methods Boswellic acid extract (1 g/​kg) was force-fed to rats seven days prior to administration of BL or gamma irradiation or both. BL (0.15 U/​rat) in 25 [mu]l of 0.9% normal saline (NS) or 0.9% NS alone was administered intratracheally. Rats were exposed to two fractionated doses of gamma irradiation (0.5 Gy/​dose/​week) with a gamma cell-40 (Cesium-137 irradiation units, Canada) during the last two weeks of the experiment. BA was administered during BL or irradiation treatment or both. After the animals were sacrificed, bronchoalveolar lavage was performed; lungs were weighed and processed separately for biochemical and histological studies. Results In rats treated with BL, levels of transforming growth factor-[beta]1 (TGF-[beta]1) and tumor necrosis factor-[alpha] (TNF-[alpha]) were significantly elevated (P =​ 0.05 and P =​ 0.005). Hydroxyproline was highly and extensively expressed. Immunoreactive compounds were abundantly expressed, represented in the levels of macrophages infiltrate, accumulation of eosinophils and neutrophils in the lung as well as the aggregation of fibroblasts in the fibrotic area. The levels of lipoxygenase enzyme activity were significantly increased (P =​ 0.005). Antioxidant activities measured in BL-treated rats deteriorated, coupled with the elevation of both levels of plasma lipid peroxide (LP) content and bronchoalveolar lavage lactate dehydrogenase activity. BA-treated rats had reduced number of macrophages, (P =​ 0.01), neutrophils in bronchoalveolar lavage (P =​ 0.01) and protein (P =​ 0.0001). Moreover, the hydroxyproline content was significantly lowered in BA-treated rats (P =​ 0.005). BA extract inhibited the TGF-#223; induced fibrosis (P =​ 0.01) and 5-LOX activity levels (P =​ 0.005). Histologically, BA reduced the number of infiltrating cells, ameliorated the destruction of lung architecture and attenuated lung fibrosis. Conclusion BA attenuates the BL-induced injury response in rats, such as collagen accumulation, airway dysfunction and injury. This study suggests that the blocking of 5-LOX may prevent the progression of fibrosis.
Terms of Use
  • COPYRIGHT 2011 BioMed Central Ltd.
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 270551011

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