2011-11-01, English, Article, Journal or magazine article edition: A novel in vitro angiogenesis model based on a microfluidic device.(Report) Dai, XiaoZhen; Cai, ShaoXi; Ye, QunFang; ...

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Physical Description
  • Report
  • Magazine/​Journal article
Published
  • Springer, 2011 Nov
Language
  • English

Edition details

Title
  • A novel in vitro angiogenesis model based on a microfluidic device.(Report)
Also Titled
  • A novel in vitro angiogenesis model based on a microfluidic device.
Appears In
  • Chinese Science Bulletin, v.56, no.31, 2011 Nov, p.3301(9) (ISSN: 1001-6538)
Author
  • Dai, XiaoZhen
  • Cai, ShaoXi
  • Ye, QunFang
  • Jiang, JiaHuan
  • Yan, XiaoQing
  • Xiong, Xin
  • Jiang, QiFeng
  • Wang, Albert Chih-Lueh
  • Tan, Yi
Published
  • Springer, 2011 Nov
Physical Description
  • Report
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • Byline: XiaoZhen Dai (1), ShaoXi Cai (1), QunFang Ye (1), JiaHuan Jiang (1), XiaoQing Yan (1), Xin Xiong (2), QiFeng Jiang (1), Albert Chih-Lueh Wang (3), Yi Tan (1,4,5) Keywords: angiogenesis; microfluidic device; microenvironment; pro-angiogenic factors Abstract: Angiogenesis is very important for many physiological and pathological processes. However, the molecular mechanisms of angiogenesis are unclear. To elucidate the molecular mechanisms of angiogenesis and to develop treatments for "angiogenesis-dependent" diseases, it is essential to establish a suitable in vitro angiogenesis model. In this study, we created a novel in vitro angiogenesis model based on a microfluidic device. Our model provides an in vivo-like microenvironment for endothelial cells (ECs) cultures and monitors the response of ECs to changes in their microenvironment in real time. To evaluate the potential of this microfluidic device for researching angiogenesis, the effects of pro-angiogenic factors on ECs proliferation, migration and tube-like structure formation were investigated. Our results showed the proliferation rate of ECs in 3D matrix was significantly promoted by the pro-angiogenic factors (with an increase of 59.12%). With the stimulation of pro-angiogenic factors gradients, ECs directionally migrated into the Matrigel from low concentrations to high concentrations and consequently formed multi-cell chords and tube-like structures. These results suggest that the device can provide a suitable platform for elucidating the mechanisms of angiogenesis and for screening pro-angiogenic or anti-angiogenic drugs for "angiogenesis-dependent" diseases. Author Affiliation: (1) Key Laboratory of Biorheological Science and Technology (Chongqing University) of Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China (2) Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China (3) Muscle and Motility Group, Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA, 02472, USA (4) Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical College, Chashan College Park, Wenzhou, 325035, China (5) Pediatric Diabetes Research at KCHRI of the Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA Article History: Registration Date: 18/​10/​2011 Received Date: 22/​02/​2011 Accepted Date: 18/​05/​2011 Online Date: 20/​10/​2011 Article note: This article is published with open access at Springerlink.com
Terms of Use
  • COPYRIGHT 2011 Springer
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 270279615

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