2011-08-01, English, Article, Journal or magazine article edition: Clinical spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature.(Report) Vaidyanathan, Gayatri; Ngamphaiboon, Nuttapong; Hernandez-Ilizaliturri, Francisco J.

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Physical Description
  • Report
  • Magazine/​Journal article
Published
  • Springer, 2011 August
Language
  • English

Edition details

Title
  • Clinical spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature.(Report)
Also Titled
  • Clinical spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature.
Appears In
  • Annals of Hematology, v.90, no.8, 2011 August, p.955(8) (ISSN: 0939-5555)
Author
  • Vaidyanathan, Gayatri
  • Ngamphaiboon, Nuttapong
  • Hernandez-Ilizaliturri, Francisco J.
Published
  • Springer, 2011 August
Physical Description
  • Report
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • Byline: Gayatri Vaidyanathan (1), Nuttapong Ngamphaiboon (2), Francisco J. Hernandez-Ilizaliturri (2,3) Keywords: Follicular lymphoma; Blastoid transformation; Double hit; Rituximab Abstract: Follicular lymphoma (FL) with blastoid transformation (FL-BT) is a rare entity. FL-BT has a dismal prognosis due to intrinsic biological characteristics, lack of evidence-based therapeutic guidelines, and exclusion from clinical trials. In order to understand the natural course of the disease and reconcile treatment strategies in patients with FL-BT, we reviewed available data. Thirty patients were identified, three from our institution (Roswell Park Cancer Institute) and 27 patients from peer-reviewed literature. Demographic, clinical, treatment, pathological, and cytogenetic characteristics were described. Most of the patients (90%) were treated with chemotherapy at transformation. Complete and partial responses to treatment were observed in 38.9% and 22.3% of the patients, respectively. The median overall survival for the entire group of patients was 11 months (range 0.8--30 months) half of the patients were found to have concurrent genetic alterations in the BCL-2 and C-MYC gene rearrangements (double hit). FL-BT with a double hit had a shorter median overall survival when compared to nondouble hit FL-BT (7 months vs. 26 months, respectively, P=​0.005). In our experience, FL-BT is a rare and grave clonal evolution in FL characterized by an aggressive clinical course, inferior response to standard chemoimmunotherapy, and poor clinical outcome. C-MYC rearrangements are common in FL-BT and may play a role in the progression from FL to FL-BT or the poor clinical outcomes observed. Periodic updates from academic institutions treating FL-BT may improve patient care. Author Affiliation: (1) Department of Internal Medicine, State University of New York at Buffalo, Elm and Carlton Streets, Buffalo, NY, 14263, USA (2) Department of Medical Oncology, State University of New York at Buffalo, Elm and Carlton Streets, Buffalo, NY, 14263, USA (3) Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA Article History: Registration Date: 17/​01/​2011 Received Date: 17/​09/​2010 Accepted Date: 17/​01/​2011 Online Date: 01/​02/​2011
Terms of Use
  • COPYRIGHT 2011 Springer
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 260945358

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