English, Article edition: EVOLUTIONARY DESIGN OF GENETIC CIRCUITS AND CELL-CELL COMMUNICATIONS YOHEI YOKOBAYASHI; CYNTHIA H. COLLINS; JARED R. LEADBETTER; ...

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Bookmark: http://trove.nla.gov.au/version/133929
Physical Description
  • article
Language
  • English

Edition details

Title
  • EVOLUTIONARY DESIGN OF GENETIC CIRCUITS AND CELL-CELL COMMUNICATIONS
Author
  • YOHEI YOKOBAYASHI
  • CYNTHIA H. COLLINS
  • JARED R. LEADBETTER
  • FRANCES H. ARNOLD
  • RON WEISS
Physical Description
  • article
Notes
  • Synthetic genetic circuits are artificial networks of transcriptional control elements inserted into living cells in order to 'program' cellular behavior. We can extend this application to programming population behavior by incorporating cell-cell communications capabilities. By designing and building such networks, cellular circuit engineers expect to gain insight into how natural genetic networks function with remarkable robustness, stability, and adaptability to changing environments. Programmed cells also have promising applications in biotechnology and medicine. A major challenge that biological circuit engineers face is the difficulty of predicting circuit performance at the design stage, with the consequence that actual construction requires significant experimental effort, even for very simple circuits. To address this fundamental obstacle we propose the use of laboratory evolution methods to create new circuit components and optimize circuit performance inside living cells.
  • Genetic circuit, directed evolution, quorum sensing, cell-cell communications, genetic regulatory networks
  • RePEc:wsi:acsxxx:v:06:y:2003:i:01:p:37-45
Language
  • English
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