The paper revisits the success case of Boston Route 128 in commercializing technology. The study applies the concept of industrial clusters to explain the development of technologically sophisticated region of Boston Route 128. Boston Route 128 has transformed its structure from the minicomputer and microprocessor-based technology industry in the 1980s to biotechnology industry in the late 1990s and 2000s. It is argued that the successful commercialization process of Boston Route 128 is rooted in innovation, entrepreneurial management and the policy towards technology commercialization. To consider the argument, the paper proposes the cluster model to explain the strengths of Boston Route 128 in biotech clusters. It represents a model of the universities working with industries to form a cluster of high technology based firms. The venture capital accelerates the process of technology commercialization, giving rise to a new Boston model of innovation management. Policy makers may use the Boston model as a benchmark to evaluate their performance in supporting Hi-Tech industries.
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