English, Article edition: Economic Evaluation of Antibacterials in the Treatment of Acute Sinusitis Claudine Laurier; Jean Lachaine; Murray Ducharme

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Bookmark: http://trove.nla.gov.au/version/119768
Physical Description
  • article
Language
  • English

Edition details

Title
  • Economic Evaluation of Antibacterials in the Treatment of Acute Sinusitis
Author
  • Claudine Laurier
  • Jean Lachaine
  • Murray Ducharme
Physical Description
  • article
Notes
  • Objective: The objective of this study was to compare costs, efficacy and cost efficacy of alternate oral antibacterial regimens for the ambulatory treatment of acute sinusitis. A public third-party perspective was adopted. Design: The analysis was based on a decision tree and considered the episode of care from the decision to initiate an antibacterial until the end of the first course of treatment or the end of a subsequent course of treatment when needed. Efficacy data were retrieved from published clinical trials. Direct medical costs included the costs of physician visits, diagnostic tests and medications. Setting: The study pertained to adults treated in a primary-care setting in the Canadian province of Quebec. Interventions: The antibacterials studied were amoxicillin, amoxicillin/​clavulanate, azithromycin, cefaclor, cefuroxime axetil and clarithromycin. Main outcome measures and results: The main outcome measured was the proportion of patients showing resolution or improvement of their symptoms. Initiating a treatment with amoxicillin was associated with similar efficacy and lower overall costs when compared with the other antibacterials. Low dosages of clarithromycin and azithromycin followed amoxicillin in terms of cost-efficacy ratio. Conclusions: This study confirms the place of amoxicillin as a first choice agent for acute sinusitis, with low dose clarithromycin and azithromycin as second choices.
  • Pharmacoeconomics, Sinusitis, Cost-analysis, Amoxicillin, Amoxicillin.clavulanic-acid, Azithromycin, Cefaclor, Cefuroxime-axetil, Clarithromycin, Antibacterials
  • RePEc:wkh:phecon:v:15:y:1999:i:1:p:97-113
Language
  • English
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