English, Article edition: Peginterferon alpha-2a (40kD) [Pegasys(R)] Improves HR-QOL Outcomes Compared with Unmodified Interferon alpha-2a [Roferon(R)-A]: In Patients with Chronic Hepatitis C Jens Rasenack; Stefan Zeuzem; S. Victor Feinman; ...

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Physical Description
  • article
Language
  • English

Edition details

Title
  • Peginterferon alpha-2a (40kD) [Pegasys(R)] Improves HR-QOL Outcomes Compared with Unmodified Interferon alpha-2a [Roferon(R)-A]: In Patients with Chronic Hepatitis C
Author
  • Jens Rasenack
  • Stefan Zeuzem
  • S. Victor Feinman
  • E. Jenny Heathcote
  • Michael Manns
  • Eric M. Yoshida
  • Mark G. Swain
  • Edward Gane
  • Moises Diago
  • Dennis A. Revicki
  • Amy Lin
  • Neil Wintfeld
  • Jesse Green
Physical Description
  • article
Notes
  • Background: Use of unmodified interferon alpha-2a in chronic hepatitis C is associated with impaired health-related quality of life during therapy. Treatment with peginterferon alpha-2a (40kD) provides an improved sustained response over unmodified interferon alpha-2a. Objectives: To compare health-related quality of life during treatment for patients receiving peginterferon alpha-2a (40kD) [Pegasys(R)] versus unmodified interferon alpha-2a [Roferon(R)]. Design: A randomised, international, multicentre, open-label, parallel group study. Setting: 36 centres worldwide. Patients: Interferon-naive patients (n =​ 531) with chronic hepatitis C. Interventions: Peginterferon alpha-2a (40kD) 180mug once a week (n =​ 267) for 48 weeks or unmodified interferon alpha-2a 6 million IU three times a week for 12 weeks followed by 36 weeks of 3 million IU three times a week (n =​ 264). Measurements: Fatigue Severity Scale and 36-item Short-Form Health Survey (SF-36). Results: At weeks 2 and 12, differences favouring peginterferon alpha-2a (40kD) were seen on seven of eight domains and both summary scores of the SF-36 (p < 0.05 to p < 0.01). At weeks 2, 12 and 24, patients receiving peginterferon alpha-2a (40kD) had less disabling fatigue (p < 0.01) than those receiving unmodified interferon alpha-2a. Conclusion: Treatment with peginterferon alpha-2a (40kD) is associated with less disabling fatigue and less impairment in patient functioning and well-being during treatment than unmodified interferon alpha-2a. In addition to safety and efficacy, the impact on health-related quality of life may be an important consideration for physicians when selecting an optimal treatment regimen.
  • Antivirals, Hepatitis C, Interferon alpha 2a, PEG interferon alpha 2a, Pharmacoeconomics, Quality of life
  • RePEc:wkh:phecon:v:21:y:2003:i:5:p:341-349
Language
  • English
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