English, Article edition: Growth Hormone Therapy and Quality of Life in Adults and Children Deborah J. Radcliffe; Joseph S. Pliskin; J.B. Silvers; ...

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Physical Description
  • article
Language
  • English

Edition details

Title
  • Growth Hormone Therapy and Quality of Life in Adults and Children
Author
  • Deborah J. Radcliffe
  • Joseph S. Pliskin
  • J.B. Silvers
  • Leona Cuttler
Physical Description
  • article
Notes
  • A fundamental goal of growth hormone (GH) treatment for both adults and children is improvement in quality of life (QOL). Assessments of the therapeutic role of GH depend on its effectiveness in meeting this and other goals (including improved metabolic status in adults and improved growth in children) in relation to economic parameters. However, there are difficulties in interpreting data on GH treatment and QOL. These include controversy about appropriate definitions and measures for assessing QOL, disease adaptation, comorbid conditions, and potential patient selection bias. In GH-deficient adults who have completed linear growth, there is considerable evidence that GH exerts effects on body composition, serum lipids, and bone and mineral density. Several controlled trials have also examined the effect of GH treatment on QOL in GH-deficient adults. They generally indicate improvement in QOL with GH treatment, although there are inconsistencies in the data. Caveats include differing outcome measures and instruments, instruments that are not disease specific, variation in characteristics of patient samples and treatment protocols, evidence of a placebo effect, and some inconsistency among results. Open-label trials in adults also suggest improvement in QOL with GH treatment, although interpretation is limited by potential placebo effects and patient self-selection. Studies in children have generally addressed psychological status, and relatively few specifically focus on QOL. In children with classical GH deficiency, it is intuitive that GH treatment will improve QOL, although hard data are lacking. In children with idiopathic short stature, evidence for improved QOL as a result of GH treatment is not well developed. Translating changes in QOL, together with physiological and metabolic benefits, into economic cost-benefit or cost-effectiveness analyses are needed. In doing so, it will be important to consider subgroups of patients who may derive differential benefit from GH treatment. These analyses are central to the development of a framework for research, decision making, and policy for GH treatment.
  • Cost-effectiveness, Growth-hormones, Quality-of-life, Somatotropin-deficiency
  • RePEc:wkh:phecon:v:22:y:2004:i:8:p:499-524
Language
  • English
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