English, Article edition: Cost Evaluation of Basiliximab Treatment for Renal Transplant Patients in Japan Tomonori Hasegawa; Hidehiko Imai; Sunao Miki

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Bookmark: http://trove.nla.gov.au/version/118723
Physical Description
  • article
Language
  • English

Edition details

Title
  • Cost Evaluation of Basiliximab Treatment for Renal Transplant Patients in Japan
Author
  • Tomonori Hasegawa
  • Hidehiko Imai
  • Sunao Miki
Physical Description
  • article
Notes
  • Background: International phase III studies (CHIB 201 and 352) showed that basiliximab, a high affinity chimeric monoclonal antibody interleukin-2 receptor antagonist, is highly effective in preventing acute rejection when used as immunoprophylaxis in patients receiving cyclosporin (Neoral(R)). We conducted a cost evaluation by applying international clinical results to standard Japanese medical practice. Objective: To evaluate the impact of basiliximab in renal transplant patients receiving conventional immunosuppressive therapy using cyclosporin and corticosteroids from the perspective of the healthcare payer in Japan. Study design: A decision tree model was developed, comprising seven pathways with key clinical events identified after the transplantation. The average first-year treatment costs after transplantation for patients treated with and without basiliximab were calculated using the model. A sensitivity analysis was done to measure the degree of influence of several criteria including the incidences of rejection, and rejection responding to steroid pulse therapy and antibody therapy. Methods: Estimates of key clinical events were derived from the international studies. Calculation of direct medical costs were made from the payers Main outcome measures and results: Basiliximab use produced an estimated saving of Yen315 Conclusions: If the cost of basiliximab is less than Yen315
  • Basiliximab, Cost-analysis, Immunosuppressants, Interleukin-2-receptor-antagonists, Pharmacoeconomics, Renal-transplant-rejection
  • RePEc:wkh:phecon:v:21:y:2003:i:11:p:791-806
Language
  • English
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