English, Article edition: Economic Benefits of Amlodipine Treatment in Patients with Coronary Artery Disease Roman Casciano; John J. Doyle; John Chen; ...

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Bookmark: http://trove.nla.gov.au/version/118548
Physical Description
  • article
Language
  • English

Edition details

Title
  • Economic Benefits of Amlodipine Treatment in Patients with Coronary Artery Disease
Author
  • Roman Casciano
  • John J. Doyle
  • John Chen
  • Steve Arikian
  • Julian Casciano
  • Heather Kugel
  • Raul Arocho
Physical Description
  • article
Notes
  • Objective: To estimate the potential savings in overall cardiovascular disease (CVD) treatment costs for the US population with coronary artery disease (CAD) resulting from the use of amlodipine. Study design and methods: Using patient-level data from a retrospective analysis of the Prospective Evaluation of the Vascular Effects of Norvasc Trial (PREVENT), a randomised, placebo-controlled clinical trial (n =​ 825), we constructed a Markov cohort simulation model to estimate the health economic outcomes of patients with CAD treated with either amlodipine or placebo. Perspective: Healthcare payer perspective. Results: The expected number of CVD events for amlodipine recipients was significantly lower than the number of CVD events in the placebo cohort (p < 0.01). The net present value of the cost per patient for CVD treatment was estimated to be $US14 117 for amlodipine recipients and $US16 683 (1999 values, assuming a 3% discount rate) for placebo recipients over 3 years of follow-up with cost savings realised in the amlodipine cohorts after 6 months. Conclusions: According to the model, amlodipine results in an expected per patient cost savings of $US2566 over a 3-year period, mainly due to a reduction in hospitalisations for cardiovascular-related events and procedures.
  • Amlodipine, Coronary disorders, Cost effectiveness, Ischaemic heart disorder therapies, Pharmacoeconomics
  • RePEc:wkh:phecon:v:20:y:2002:i:8:p:553-563
Language
  • English
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