English, Article edition: Gastrointestinal-Related Healthcare Resource Usage Associated with a Fixed Combination of Diclofenac and Misoprostol versus Other NSAIDs Elham Rahme; Lawrence Joseph; Sheldon X. Kong; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/118241
Physical Description
  • article
Language
  • English

Edition details

Title
  • Gastrointestinal-Related Healthcare Resource Usage Associated with a Fixed Combination of Diclofenac and Misoprostol versus Other NSAIDs
Author
  • Elham Rahme
  • Lawrence Joseph
  • Sheldon X. Kong
  • Douglas J. Watson
  • James M. Pellissier
  • Jacques LeLorier
Physical Description
  • article
Notes
  • Objective: To compare gastrointestinal (GI) healthcare resource use (HCRU) and associated costs in patients taking a fixed combination of diclofenac and misoprostol versus other nonsteroidal anti-inflammatory drugs (NSAIDs). Methods: We analysed a sample (49 033 patients) of the Government of Quebec Health Insurance Agency database. Patients were included in the study if they did not have GI events during the year preceding the date of their first NSAID prescription dispensing (the index date). Patients were followed up for 2 years. A 3-stage model was used to determine the factors that influenced the direct medical costs of GI HCRU: 1. a logistic regression model (model 1) to estimate the risk of GI HCRU; 2. a linear regression model (model 2) to estimate the direct costs of GI HCRU for those who had such events; 3. multiplying the estimated risks from model 1 by the estimated costs from model 2 gave the estimated direct costs of GI HCRU for all patients. Study Perspective: Provincial government of Quebec, Canada. Results: 1533 patients were prescribed diclofenac/​misoprostol at the index date and 10 540 another NSAID. Comorbidity markers were not significantly different between the 2 groups. Of the diclofenac/​misoprostol patients, 23 (1.5%) were hospitalised for GI problems compared with 194 (1.8%) of the NSAID group; 403 (26.3%) of diclofenac/​misoprostol patients used gastroprotective agents compared with 2849 (27.0%) of the NSAID patients; 118 (7.7%) of diclofenac/​ misoprostol patients had GI diagnostic tests compared with 682 (6.5%) of the NSAID patients. The average direct medical cost of GI HCRU was 310.52 Canadian dollars ($Can) /​patient (1997 values) in the diclofenac/​misoprostol group compared with $Can231.19/​patient (1997 values) in the NSAID group. When adjusted for baseline factors, the ratio of the total direct medical cost of GI HCRU in the diclofenac/​misoprostol group to that of the NSAID group was 1.15 (95% confidence interval: 0.89, 1.48). Conclusions: Our data showed no significant differences in GI HCRU among patients taking diclofenac/​misoprostol compared with those taking NSAIDs.
  • Cost analysis, Diclofenac/​misoprostol, Gastrointestinal disorders, Gastrointestinal disorders, Nonsteroidal anti inflammatories, Pharmacoeconomics, Resource use
  • RePEc:wkh:phecon:v:19:y:2001:i:5:p:577-588
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment