In recent years, cities have become increasingly interested in their ability to generate, attract and retain human capital. One measure of human capital is employment in science- and engineering-based occupations. This paper provides a comparison of the employment shares of these specialized occupations across Canadian and U.S. cities by using data from the Canadian and the U.S. censuses from 1980-1981 and 2000-2001. The paper, therefore, provides a perspective on how Canadian cities performed relative to their U.S. counterparts over a twenty-year period. It also seeks to evaluate how cities of different sizes have performed, because large cities may be advantaged over smaller cities in terms of factors influencing both the demand for, and supply of, scientists and engineers.