Emmanuele de Beaupuis studied at the Naples Royal Conservatory with Benjamin Cesi, who had himself been a pupil of Austrian virtuoso pianist Sigismond Thalberg. On leaving the Conservatory he made a series of successful professional tours through the principal towns of Italy, Egypt, France, and England.
After six years in Cairo, de Beaupuis moved to Melbourne in 1889 and developed a reputation as a virtuoso pianist. He toured Australia and South Africa in 1893. From about 1896 he taught and performed in Sydney. He was associated with Paling's as a teacher. He taught piano and theory and became a mentor to Roy Agnew. Agnew later dedicated works to Madame de Beaupuis (Bertha Kerr, nee Lord, whom de Beaupuis had married in 1903).
de Beaupuis wrote numerous works for piano, including concert and salon works. He also arranged and edited for piano the works of numerous other composers, including Kowalski, Gounoud, Liszt, and Beethoven. His Sur la Mer and Ave Maria were well known.